移植受者SARS-CoV-2感染后IgG，而不是IgA，抗spike抗体的延迟动力学JF -美国肾病学会杂志万博体育max3Soc。Nephrol。- 10.1681 / ASN.2021040573吗SP - ASN.2021040573盟Cravedi保罗AU -哈恩,帕特里克·王盟——林盟——Yalamarti Tanuja AU - Hartzell,苏珊盟——Azzi Yorg盟,梅农Madhav c . AU - Jain Aditya AU -比拉王储,Marzuq AU - Fernandez-Vina,马塞洛非盟-山丘,霍华德·m . AU -伍德尔e . Steve AU -哈达德,娜塔莉·s . AU - Morrison-Porter安德里亚盟-李,F. Eun-Hyung AU - Sanz, Ignacio AU - Akalin, Enver AU - Girnita, Alin AU - Maltzman, Jonathan S. Y1 - 2011/11/15 UR - //www.inmeli.com/content/early/2021/11/14/ASN.2021040573.abstract N2 -发病率分析，相对动力学，肾移植受者的抗sars - cov -2抗体谱不像免疫能力对照组那么详细。在这项多中心、横断面研究中，我们对49例经pcr证实的SARS-CoV-2感染的肾移植受者进行了研究，发现抗SARS-CoV-2 IgG的产生被延迟，但IgM和IgA反应与免疫能力对照组中观察到的反应相似。因此，抗病毒体液免疫在肾移植受者中被延迟但被保留。这一发现对于了解慢性免疫抑制患者对SARS-CoV-2的免疫反应很重要，并可能为制定策略监测抗体对感染的反应和疫苗接种提供见解。在COVID-19期间，肾移植受者发生严重后果的风险增加。 Antibodies against the virus are thought to offer protection, but a thorough characterization of anti–SARS-CoV-2 immune globulin isotypes in kidney transplant recipients following SARS-CoV-2 infection has not been reported.Methods We performed a cross-sectional study of 49 kidney transplant recipients and 42 immunocompetent controls at early (≤14 days) or late (>14 days) time points after documented SARS-CoV-2 infection. Using a validated semiquantitative Luminex-based multiplex assay, we determined the abundances of IgM, IgG, IgG1–4, and IgA antibodies against five distinct viral epitopes.Results Kidney transplant recipients showed lower levels of total IgG antitrimeric spike (S), S1, S2, and receptor binding domain (RBD) but not nucleocapsid (NC) at early versus late time points after SARS-CoV-2 infection. Early levels of IgG antispike protein epitopes were also lower than in immunocompetent controls. Anti–SARS-CoV-2 antibodies were predominantly IgG1 and IgG3, with modest class switching to IgG2 or IgG4 in either cohort. Later levels of IgG antispike, S1, S2, RBD, and NC did not significantly differ between cohorts. There was no significant difference in the kinetics of either IgM or IgA antispike, S1, RBD, or S2 on the basis of timing after diagnosis or transplant status.Conclusions Kidney transplant recipients mount early anti–SARS-CoV-2 IgA and IgM responses, whereas IgG responses are delayed compared with immunocompetent individuals. These findings might explain the poor outcomes in transplant recipients with COVID-19. ER -